The association between obesity, dyslipidaemia, and pre-diabetes: Insights from current evidence

• Author Details:   
• Vijaylaxmi Abhijeet Shende ^*
• Rita S Mishra

---

Background: This study examines the relationship between obesity, dyslipidemia, and pre-diabetes in a large Indian population.  It also assesses the potential of triglycerides (TG) as an early biomarker for pre-diabetes and looks at gender-based differences, especially in younger males.

Materials and Methods: Between October 2022 and July 2023, a cross-sectional, quantitative investigation was carried out at a clinical diagnostic centre in India. Based on glyceated haemoglobin (HbA1c) levels (5.7%–6.4%), 404 people with pre-diabetes and 336 non-diabetic controls were identified among 5,687 screened adults (?18 years). Chi-square and independent t-tests were used to examine the demographic, body mass index (BMI), waist circumference (WC), and lipid profile data.

Results: The prevalence of pre-diabetes was 7.1%. A substantial relationship was found between increased BMI and pre-diabetes, with the majority of those affected being overweight or obese. Central obesity, as measured by waist circumference, was also strongly associated with pre-diabetes. Although a gender-wise subgroup analysis revealed a higher incidence of pre-diabetes among younger males (<40 xss=removed xss=removed xss=removed xss=removed>

Conclusion: Obesity and increased LDL-C levels emerge as important predictors of pre-diabetes. Early detection and focused therapies are critical, especially in people with obesity and lipid problems. Additional large-scale investigations are needed to validate these findings and investigate the function of TG in pre-diabetes progression.

Keywords: Obesity, Dyslipidemia, Pre-diabetes, Metabolic syndrome, Insulin resistance