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Exploiting lemon peel extract in orodispersible granule formulation using green banana flours as natural superdisintegrant

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Original Article

Author Details : Afroj Ayyaj Shaikh*, Sayali G Zambare, Digvijaysingh R. Kale, Ahamefula Anslem Ahuchaogu

Volume : 7, Issue : 1, Year : 2024

Article Page : 22-30

https://doi.org/10.18231/j.ijnmhs.2024.005

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Abstract

Background: Amidst the global COVID-19 pandemic, there is an urgent need to bolster immunity. This study endeavors to address this necessity by formulating orodispersible herbal granules enriched with lemon peel extract, recognized for its immune-boosting attributes.
Materials and Methods:  The extraction of lemon peel was facilitated through ultrasound, followed by meticulous evaluations encompassing color, solubility, and yield. Disintegrants, ranging from 2% to 6% concentrations of banana flour, were incorporated into granule formulations. The compatibility of lemon peel extract with other constituents was scrutinized via FTIR and DSC analyses. Utilizing a design-of-experiment (DoE) strategy employing a 32 full factorial design, formulations were synthesized and assessed for various parameters, including flow properties, density, disintegration time, and release attributes.
Results:  Analysis revealed lemon peel extract's significant phenolic content (185 mg Gallic acid equivalent/gm) and flavonoid content (170 gm Quercetin equivalent/gm of extract). The orodispersible granules exhibited favorable flow properties, demonstrating rapid dissolution within 45 to 59 seconds. In vivo assessments showcased heightened immune-boosting efficacy. Moreover, the optimized batch displayed superior in-vivo bioavailability, attaining a peak plasma concentration at 1 hour (88.47 ng/ml).
Conclusion: The successful development of herbal granules amalgamating lemon peel extract and banana flour underscores their potential to enhance immunity during the COVID-19 pandemic. These formulations exhibit commendable attributes of quality, consistency, and stability, promising substantial benefits in augmenting immune response.

Keywords: Immunity, Orodispersible, Disintegration, Extrusion spheronization, Phenolic content

How to cite : Shaikh A A, Zambare S G, Kale D R, Ahuchaogu A A, Exploiting lemon peel extract in orodispersible granule formulation using green banana flours as natural superdisintegrant. J Nutr Metab Health Sci 2024;7(1):22-30

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