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Evaluation of immunoglobulin M and A level in individuals with HIV-TB co-infection in NAUTH, Nnewi

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Original Article

Author Details : IP Ezeugwunne, N Mbachu, PC Arinzechi, EC Ogbodo*, RA Analike, IO Uduchi, ECO Izuchukwu, NS Nduka

Volume : 4, Issue : 4, Year : 2021

Article Page : 182-189

https://doi.org/10.18231/j.ijnmhs.2021.032

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Abstract

This study evaluated the serum concentrations of Immunoglobulin M and Immunoglobulin A in individuals with TB, HIV and HIV-TB co-infection in Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi South East, Nigeria. A total of 80 participants (males=44; females=36), with a mean age of 35.83±7.3 were randomly recruited by convenient sampling technique from patients attending TB-DOTS and HIV Clinics in NAUTH and grouped as: TB positive individuals (Group I), HIV-TB co-infection (Group II), HIV positives (Group III), and control (Group IV). 5mls of venous blood samples were collected from each participants using plain containers for estimation of immunoglobulin A and M classes by Immuno-turbidimetric Method. The results obtained showed that mean serum levels of IgM (78.14±42.41 and IgA (374.45±15.69) were significantly increased in participants with HIV-TB co-infection when compared with TB (49.21±3.67) and (315.41±52.79), HIV (41.91±25.97) and (342.23±92.67 and control groups (55.82±35.36) and (322.66±71.34) at p<0 p=0.048), p=0.000) p=0.001) p=0.013) p=0.005),>

Keywords: HIV, TB, HIV-TB co-infection, Immunoglobulins, NAUTH.

How to cite : Ezeugwunne I, Mbachu N, Arinzechi P, Ogbodo E, Analike R, Uduchi I, Izuchukwu E, Nduka N, Evaluation of immunoglobulin M and A level in individuals with HIV-TB co-infection in NAUTH, Nnewi. J Nutr Metab Health Sci 2021;4(4):182-189

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